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The toxicity of silver nanomaterials (NM 300K) is reduced when combined with N-Acetylcysteine: Hazard assessment on Enchytraeus crypticus
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Após os resultados mostrados em outros modelos, foi levantada a hipótese de que o composto quelante de tiol N-acetilcisteína poderia ser usado para reduzir os efeitos tóxicos das nanopartículas de prata em invertebrados do solo, como os entraeídeos (Enchytraeus crypticus, Oligochaeta). Este estudo apresentou novas evidências sugerindo que a N-acetilcisteína e a glutationa poderiam ser usadas para reduzir os efeitos tóxicos dos materiais Ag nos invertebrados do solo, como os entraeídeos (Oligochaeta, Enchytraeidae).
Environ Pollut. Jan 2020

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The toxicity of silver nanomaterials (NM 300K) is reduced when combined with N-Acetylcysteine: Hazard assessment on Enchytraeus crypticus
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We hypothesized that the thiol-chelating compound N-acetylcysteine (NAC) could be used to reduce the toxic effects of AgNPs on soil invertebrates such as enchytraeids (Enchytraeus crypticus,Oligochaeta). This study presented novel evidence suggesting that N-Acetylcysteine (NAC) and glutathione (GSH) could be used to reduce the toxic effects of Ag materials on soil invertebrates such as enchytraeids (Oligochaeta, Enchytraeidae).
Environ Pollut. Jan 2020

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Protective effect of N-acetylcysteine on the toxicity of silver nanoparticles: Bioavailability and toxicokinetics in Enchytraeus crypticus.
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Neste estudo demonstramos que a toxicidade de nanopartículas de prata (AgNPs) no processo de reprodução de enchiltrídeos (Annelida: Oligochaeta) pode estar diretamente ligada à alta disponibilidade de Ag no solo; levando a aumento da bioacumulação de Ag. Mostramos também, que a acetilcisteína (NAC) protege o Enchytraeus crypticus da toxicidade das AgNPs, reduzindo a concentração de Ag dentro dos organismos. Por fim, concluímos que o NAC poderia ser uma alternativa eficaz para remediação e recuperação de organismos terrestres expostos a solos contaminados por metais.
Sci Total Environ. Jan 2020

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Protective effect of N-acetylcysteine on the toxicity of silver nanoparticles: Bioavailability and toxicokinetics in Enchytraeus crypticus.
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This study demonstrated that the toxicity of AgNPs to enchytraeid (Annelida: Oligochaeta) reproduction may be directly linked with high Ag availability in the soil therefore resulting in increased Ag bioaccumulation. NAC protects the Enchytraeus crypticus from toxicity of the AgNPs by reducing the concentration of Ag inside the organisms, rather than the rate at which Ag is entering the organism. Overall, we conclude that NAC could be an effective alternative for early remediation and recovery of terrestrial organisms exposed to metal-contaminated soils.
Sci Total Environ. Jan 2020

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